Silybum marianum (milk thistle) has been used for centuries to support liver function.* Silymarin's hepatoprotective effects are accomplished via several mechanisms, including antioxidation, inhibition of lipid peroxidation, enhanced liver detoxification via inhibition of phase I detoxification and enhanced glucuronidation, and protection of glutathione depletion.* Siliphos consists of the most potent flavonoid in silymarin (silybin) bound to phosphatidylcholine for enhanced hepatoprotection and bioavailability.*

Curcumin, an active flavonoid from turmeric, has potent antioxidant, hepatoprotective, and gastroprotective properties.* Curcumin is bound to phosphatidylcholine in the highly bioavailable phytosome complex – Meriva.* Cynara scolymus (artichoke) has a long history of use in hepatic support.*

Picrorhiza is used in Ayurvedic medicine to optimize liver function.* In studies, Picrorhiza extracts and their constituents protected liver cells from damage caused by carbon tetrachloride, aflatoxin B1, and acetaminophen.* Picrorhiza acts as an antioxidant and inhibitor of lipid peroxidation in cell membranes, and it also increases bile flow.* The hepatoprotective effects of Picrorhiza may be due to its antioxidant activity – inhibition of oxygen anion generation and free-radical scavenging.* Like silymarin, Picrorhiza can stimulate liver regeneration, possibly via stimulation of nucleic acid and protein synthesis.*