Indole-3-carbinol (I3C) is a phytochemical derived in high concentrations from the Brassica family of vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. I3C and its derivative compounds have been shown to exert anticancer mechanisms in the human body. I3C has been shown to exhibit direct antiestrogenic activity via competitive inhibition of estrogen receptors; upregulate the cytochrome P450 isoenzymes CYP1A1, CYP1A2, and CYP1B1, thereby increasing estrogen metabolism; shift estrogen metabolism away from the more proliferative (16‑OHE1) towards the more protective (2‑OHE1) estrogen species; induce cancer cell apoptosis via NF‑κB pathways; inhibit cancer cell growth at the G1 stage; and increase the expression of p21, p27 and p53 tumor suppressors. The use of I3C for the prevention and treatment of breast, endometrial, colon, and prostate cancers as well as for the treatment of herpes simplex virus (HSV) and human papillomavirus (HPV), including cervical dysplasia and cervical cancer, has been studied in depth in both animals and humans with favourable results.

 

 

Suggested Use / Directions:

Suggested Use:
Take 1-3 capsules daily or as directed by your licensed health-care practitioner.

Serving Size:
1 vegetable capsule

Medicinal Ingredients:

Each non-GMO vegetable capsule contains:

Non-Medicinal Ingredients:
Vegetable magnesium stearate and microcrystalline cellulose in a capsule composed of vegetable carbohydrate gum and purified water.


Cautions and warnings: Consult a healthcare practitioner prior to use if you are taking medications or natural health products; if you are attempting to conceive; if you have symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness, or irregular menstruations); and to exclude the diagnosis of a serious cause of hormonal imbalance. Discontinue use and consult a healthcare practitioner if you develop liver-related symptoms (e.g. yellowing of the eyes and/or skin, dark urine, abdominal pain, jaundice). Contraindications: Do not use this product if you are pregnant or breast-feeding. Colour, size and smell may vary from one lot to another. Keep in a cool, dry place, protected from light. Do not use if seal is broken. Keep out of reach of children.