Discovery of vitamin K-dependent (VKD) post-translational modification of proteins 
involved not only in coagulation, but also in bone metabolism, vascular calcification, cell 
growth regulation, and even ATP production has dramatically shifted both the 
physiological and clinical importance of this enzymatic cofactor.1,2,3 VKD proteins have a 
nearly ubiquitous presence in diverse cell types, and modification by γ-carboxylation is 
necessary for biological activity. Dietary intake of vitamin K is often insufficient, and 
vitamin K is diverted to those enzymes critical to short term survival (e.g. coagulation), 
leading to suboptimal carboxylation of VKD proteins associated with aging and chronic 
disease, such as matrix Gla protein, osteocalcin and Gas6.4
Clinically, a lower intake of vitamin K has translated into a greater risk for myocardial 
infarction and stroke, plaque instability, and most recently, diabetes.5,6 A greater intake 
of vitamin K, particularly K2, has been associated with lower all-cause mortality, coronary 
heart disease, aortic calcification, as well as cancer incidence and fatality.7,8 Higher intake 
of MK-7, which has the longest half-life and the most extra-hepatic distribution, has 
been associated with lower risk of fracture and greater BMD
1 capsule per day or as directed by a health care practitioner.

Supplement Facts Serving Size: 1 Vegetarian Capsule 

Each Tablet Contains: 
Vitamin K2 (Menaquinone) (MK-7) (Natto Bean) .................................................................100 mcg

 Non-medicinal Ingredients: Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant)
Consult a health care practitioner prior to use if you are taking blood thinners.