PharmaGABA-250

Gamma-aminobutyric acid (GABA) is a major neurotransmitter widely distributed throughout the central nervous system. Because too much excitation can lead to irritability, restlessness, sleeplessness, and spasmodic movements, this excitation needs to be balanced with
inhibition. GABA – the most important inhibitory neurotransmitter in the brain – can provide this inhibition, acting like a “brake” during times of runaway stress. In addition, studies also indicate GABA can promote relaxation and enhance sleep. It is thought that either low GABA levels or decreased GABA function in the brain may have an adverse impact on neurological health.

The natural GABA in Thorne Research’s PharmaGABA-100 and PharmaGABA-250 is produced via a fermentation process that utilizes Lactobacillus hilgardii, the bacteria used to ferment vegetables in the preparation of the traditional Korean cabbage dish known as kimchi. Clinical studies show this natural form of GABA can increase the production of alpha-waves in the brain, creating a profound sense of physical relaxation while maintaining mental focus. In contrast, the stress-related beta-waves in the brain are decreased. In addition to changes in brain waves, natural PharmaGABA has been shown to produce relaxation, as evidenced by reduced pupil diameter, heart rate,
and two natural markers of stress – salivary cortisol and chromogranin A. In a head-to-head, double-blind trial of natural PharmaGABA versus synthetic GABA, synthetic GABA did not demonstrate these positive effects.

Medicinal Ingredients:

Gamma-Aminobutyric Acid (GABA) 250 mg
(from Lactobacillus hilgardii-3)**

Non-Medicinal Ingredients:

Hypromellose (derived from cellulose) capsule, Magnesium Citrate, Magnesium Laurate, Microcrystalline Cellulose.

Recommended Dose:

Take 1 capsule, one to three times daily, or as recommended by a health-care practitioner. Take with food. Consult a health-care practitioner for use beyond 3 weeks.

Risk Information:

Consult a health-care practitioner prior to use if you are pregnant or breastfeeding. If you have epilepsy, consult a health-care practitioner prior to use. If symptoms persist or worsen, consult a health-care practitioner. Consumption with alcohol, other medications or health products with sedative properties is not recommended.