Back to catalog home

Methyl Folate L-5-MTHF

Douglas Labs



Methyl Folate L-5-MTHF product image
SKU: DL-20118160X
Methyl Folate by Douglas Laboratories supplies 1,000 mcg of biologically active folate called (6S) 5 - methyltetrahydrofolate (5- MTHF).

Folate is a water- soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can support proper neurological development in the fetus. Additionally, folate plays a key role in the metabolism of homocystei ne. Homocysteine is a sulfur containing amino acid that is created in the body from methionine, an essential amino acid derived solely from dietary intake. High plasma levels of homocysteine appear to injure the vasculature, impairing the functional abili ties of endothelial and smooth muscle cells.

Metafolin® folate is a patented, natural form of (6S) 5 - methyltetrahydrofolate (5- MTHF). 5- MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health, as it participates as a cofactor in a reaction that involves the remethylation of homocysteine to methionine. Unlike synthetic folic acid, 5- MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10 - methylenetetrahydrofolate reductase (MTHFR). In certain populations, the body’s ability to convert folic acid to 5 - MTHF by use of this enzyme may be compromised due to genetic differences. Metafolin® contains only the S isomer of 5- MTHF and has been shown to be the only form of folate to be able to cross the blood- brain barrier. Metafolin® does not appear to mask the anemia associated with a vitamin B12 deficiency and presents no risk of an accumulation of unmetabolized folic acid in the body.

Methyl Folate is a useful dietary supplement for those individuals that prefer a high dose active form of folic acid called (6S) 5 - MTHF.

Supplement Facts
1 tablet contains:
Folate 1,000mcg (250%DV)
---(as L-methylfolate, Metafolin)
Other Ingredients: Cellulose, dicalcium phosphate, croscarmellose sodium, vegetable stearate and silica.
Contains NO: yeast, gluten, soy protein, milk, dairy, corn, sugar, starch, artificial coloring, preservatives or flavoring.

Recommended Use:
Adults: As a dietary supplement, adults take 1 tablet daily or as directed by a healthcare professional.

If you are pregnant or nursing, please consult your healthcare professional before using this product. Keep out of the reach of children. Doses of 5 mg or higher per day can cause abdominal cramps, diarrhea, and rash.

Supplement Facts
Take 1 Tablet Once Per Day

Similar products
Active Chewable B12 with L-Methylfolate product image
Methyl B12 Plus product image

Methyl B12 Plus

Douglas Labs

90 tablets



L-5-MTHF 1000mcg product image

L-5-MTHF 1000mcg

Designs for Health

120 capsules

Log in for pricing

Active Folate 1000 product image

Active Folate 1000


90 capsules