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Intestamine® product image
SKU: DL-80038057
Intestamine capsules, supplied by Douglas Laboratories, is a unique and convenient dietary supplement
formula for gastrointestinal support. Intestamine provides significant amounts of L-glutamine, an amino acid
that is important in maintaining normal structure and function of the gastrointestinal tract; NutraFlora FOS,
which selectively provides nourishment for beneficial intestinal bacteria; acacia fiber, which is fermented into
short chain fatty acids for the lower intestine; and N-Acetyl-D-Glucosamine, which is used as a structural
component of intestinal mucous secretions.
Glutamine. The amino acid glutamine plays a key role in the metabolism, structure, and function of the entire
gastro-intestinal (GI) tract, and its extensive immune system. Glutamine is perhaps the major energy source
for intestinal cells, and under conditions of physiological stress the GI tract benefits greatly from extra dietary
glutamine. Glutamine is the most abundant amino acid found in blood, and is a vehicle for nitrogen transport.
Glutamine-consuming tissues, such as the GI tract, the liver, and the immune system, use glutamine for the
synthesis of nucleotides, proteins, and amino sugars. Glutamine carries potentially toxic ammonia to the
kidneys for excretion, and participates in maintaining normal acid-base balance.
The human intestinal tract removes as much as 12-13% of the circulating blood glutamine in addition to the
glutamine absorbed from dietary origin. Intestinal mucosal cells need glutamine as a nitrogen donor for the
biosynthesis of a number of important compounds, including nucleotides needed for cell division, amino sugars
for building the glycosaminoglycans of intestinal mucous, amino acids that are crucial for protein synthesis as
well as for an energy source. During physiological stress, such as starvation, physical trauma, surgery, or
inflammatory bowel disease, the intestinal tract uses very large amounts of glutamine and very little glucose for
energy. This often results in a fall of blood glutamine, and skeletal muscle is broken down to supply more
glutamine. The immune cells of mucosa, mesentary and liver depend on glutamine as a key nitrogen donor
and energy source. During infections of intestinal origin, immune cells need more glutamine, and the liver’s
glutamine consumption can rise about ten-fold. Intestinal infections, trauma or surgery can result in lower
blood glutamine levels and muscle wasting. In summary, many clinical studies support the fact that dietary
glutamine is crucial in maintaining normal function of the entire gastrointestinal tract, including the liver and
pancreas. Glutamine helps maintain normal intestinal permeability, mucosal cell regeneration, and structure.
At the same time, glutamine supports normal immune function of the gastrointestinal tract and the liver.
Most people who are concerned about their GI health will benefit significantly from about 5 to 20 grams of
supplemental L-glutamine per day. Six Intestamine capsules provide 3.75 grams of pure L-glutamine.
NutraFlora®FOS. Six Intestamine capsules also provide 187 mg of NutraFlora® brand of fructooligosaccharides (FOS), a class of natural carbohydrates. FOS are non-digestible, short-chain fructose oligomers that are utilized almost exclusively by the beneficial bacteria in the intestinal tract.
NutraFlora®FOS is a carbohydrate that passes through the small intestine into the colon without being
digested or absorbed. Once in the colon, FOS selectively feeds the beneficial symbiotic bacteria, such as
Lactobacillus acidophilus, Bifidobacteria, and other acid-producing bacteria. Regular consumption of FOS has
been shown to support healthy levels of these beneficial bacteria in the colon. This in turn creates a slightly
acidic environment in the colon that is inhospitable to potentially harmful bacteria and other microorganisms,
such as E. coli and Clostridium species.
Acacia Fiber. Intestamine supplies 375 mg of soluble, fermentable dietary fiber from acacia fiber per six
capsules. Like FOS, acacia fiber is not digested in the upper intestine, but extensively fermented by the
beneficial colonic microflora. The fermentation products are short chain fatty acids, such as acetic, propionic
and butyric acid. These short chain fatty acids have several functions in the
healthy colon. First, they provide an acid environment that favors the growth of the acid-loving beneficial
Lactobacilli and Bifidobacteria. Second, short chain fatty acids are important for colonic water absorption and
a normal stool consistency. And third, they are utilized as an energy source by the cells of the colonic mucosa.
Adequate amounts of fermentable dietary fiber appear to be necessary to maintain normal structure and
function of the colonic mucosa.
N-Acetyl-D-Glucosamine. Intestinal mucosal cells produce large amounts of mucous that are constantly
secreted into the intestinal lumen. This mucous protects the mucosal cells, and helps propel digested food
throughout the GI tract. Just like glucosamine (sold separately by Douglas Laboratories as Glucosamine
Sulfate), N-Acetyl-D-Glucosamine (NAG) is a naturally occurring amino sugar. NAG is found in
glycosaminoglycans which are major structural components in intestinal mucous secretions as well as
connective tissues. Supplementation with these amino sugars often helps maintain normal glycosaminoglycan
synthesis and intestinal mucous production. Healthy individuals can easily convert glucosamine into NAG.
However, in patients with inflammatory intestinal diseases, this conversion appears to be less effective. That’s
why for the GI tract, NAG supplementation is usually preferred over glucosamine sulfate.
Six Intestamine capsules provide 187 mg of NAG to support normal mucous production for intestinal health.
Intestamine capsules may be a useful dietary supplement for those who wish to provide dietary support for a
healthy GI tract. Intestamine can be taken regularly, and can be combined with probiotic dietary supplements,
such as Douglas Laboratories’ Bio-dophilus™ or similar products delivering beneficial living bacteria.

Six capsules contain:
L-Glutamine ................................................................. 3,750 mg
NutraFlora®*FOS (Fructooligosaccharides)................. 187 mg
Acacia Fiber (soluble dietary fiber) .............................. 375 mg
N-Acetyl-D-Glucosamine ............................................. 187 mg
NutraFlora is a registered trademark of Golden Technologies Company, Inc.
Intestamine capsules can be taken on a regular basis to maintain proper GI function. Individuals with GI and
catabolic diseases should consult a health care professional for appropriate use of Intestamine capsules for
their nutritional support. For best results, take with cold or room-temperature foods or liquids. Do not take with
foods or liquids that are hot or highly acidic.
If you have an allergy to shellfish (including crab and shrimp), you should not use this product.
No adverse side effects have been reported.
Store in a cool, dry place, away from direct light. Keep out of reach of children.

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