The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health. Preliminary studies have examined the efficacy, safety, and optimal supplementation of Indole-3-Carbinol (I3C). A 12-week phase 1 trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
Indole-3-Carbinol (3-Hydroxymethylindole) 200 mg
Microcrystalline Cellulose, Leucine, Silicon Dioxide in a Hypromellose (derived from cellulose) capsule.
Take 1 capsule one to two times daily or as recommended by a health-care practitioner.
Consult a health-care practitioner if you develop a skin rash. Consult a health-care practitioner prior to use if you are taking an antacid, H2 blocker, or proton-pump inhibitor. Consult a health-care practitioner if you are taking any medication. Consult a health-care practitioner prior to use if you are attempting to conceive. Consult a health-care practitioner prior to use if you have a liver disorder or develop liver-related symptoms (e.g., abdominal pain, jaundice), or if you have low estrogen or symptoms of low estrogen. Do not use if you are pregnant or breastfeeding.
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